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熊菲, 霍亭竹, 李平等. 宫内发育迟缓儿6月龄免疫功能与追赶生长的队列关系研究[J]. koko体育app 学报（医学版）, 2015, 46(2): 253-257.
引用本文: 熊菲, 霍亭竹, 李公平. 宫腔内成长发育发育迟缓儿6月龄免疫系统性能与追杀植物的生长的序列关联设计[J]. 河北高校学报（分子生物学版）, 2015, 46(2): 253-257.
XIONG Fei, HUO Ting-zhu, LI Ping. et al. Immune Function and Catch-up Growth of 6-month Infants with Intrauterine Growth Retardation[J]. Journal of Sichuan University (Medical Sciences), 2015, 46(2): 253-257.
Citation: XIONG Fei, HUO Ting-zhu, LI Ping. et al. Immune Function and Catch-up Growth of 6-month Infants with Intrauterine Growth Retardation[J]. Journal of Sichuan University (Medical Sciences), 2015, 46(2): 253-257.

宫内发育迟缓儿6月龄免疫功能与追赶生长的队列关系研究

Immune Function and Catch-up Growth of 6-month Infants with Intrauterine Growth Retardation

  • 摘要: 目的 研究宫内发育迟缓（intrauterine growth retardation，IUGR）儿出生后6月免疫功能和追赶生长之间的关系，探讨“发育程序化”途径对机体免疫功能的影响程度。方法 选择2010年3~12月符合纳入和排除标准并且临床均诊断为IUGR的孕晚期孕妇60例，正常对照组孕妇20例。记录妊娠结局，随访出生koko体育app 至6月龄，每月进行系统化的koko体育app 保健，测量体质量、身长，并采用Z评分法评估koko体育app 的生长发育偏离状况。在6月龄时采集外周静脉血，用流式细胞检测技术检测T淋巴细胞亚群CD3、CD4、CD8及B淋巴细胞，免疫比浊法检测IgG、IgM、IgA、C3、C4，分析宫内和宫外的追赶生长情况与免疫功能指标的关系。结果 IUGR组中小于胎龄儿（small for gestational age，SGA）的发生率为27.27%，新生儿并发症的发生率为29.09%。IUGR组新生儿的出生体质量、身长均低于对照组（\P\P\P\P\P>0.05)。结论 宫内和宫外未出现追赶生长的IUGR组婴儿到6月龄时部分免疫功能仍未恢复正常，但“发育程序化”的假说仍需要更大样本量及长期的队列研究证实。  
    Abstract: Objective To explore the influence of “developmental programming” on immunity function and the correlation between immunologic changes and physical growth. Methods Sixty singleton pregnancies with intrauterine growth retardation (IUGR) and twenty normal pregnant women were enrolled in this study at their third trimester of pregnancy. Birth weight, birth length, mode of delivery, complication of newborn were measured and/or recorded at the moment of delivery. Physical development of the infants was measured every month up to six months old using weight and length as indicators. The deviation of physical growth was evaluated by \Z score. Blood samples were taken from the infants at the sixth month. Lymphocyte subpopulations were analyzed using flow cytometry. Humoral immunity were measured using immunoturbidimetry. Results About 27.27% and 29.09% of IUGR infants were found to have small for gestational age (SGA) and neonatal complications. They had lower birth body masses and birth lengths than those of controls （\P\P\P<0.05）.Conclusion IUGR infants without intrauterine-catch-up and extrauterine-catch-up have impaired immunity function. The theory of “development program” needs proof of studies with a large sample size and long-term follow-up.  
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