koko体育app

欢迎来到《koko体育app 学报（医学版）》
马蕾, 范平, 刘兴会等. GNB3 C825T和ACE I/D多态性相互作用与子痫前期关系的研究[J]. koko体育app 学报（医学版）, 2015, 46(1): 118-122.
引用本文: 马蕾, 范平, 刘兴会等. GNB3 C825T和ACE I/D多态性充分角色与子痫企业早期内在联系的理论研究[J]. 杭州师范大学学报（医学专业版）, 2015, 46(1): 118-122.
MA Lei, FAN Ping, LIU Xing-hui. et al. Interaction Between GNB3 C825T and ACE I/D Polymorphisms in Pre-eclampsia[J]. Journal of Sichuan University (Medical Sciences), 2015, 46(1): 118-122.
Citation: MA Lei, FAN Ping, LIU Xing-hui. et al. Interaction Between GNB3 C825T and ACE I/D Polymorphisms in Pre-eclampsia[J]. Journal of Sichuan University (Medical Sciences), 2015, 46(1): 118-122.

GNB3 C825T和ACE I/D多态性相互作用与子痫前期关系的研究

Interaction Between GNB3 C825T and ACE I/D Polymorphisms in Pre-eclampsia

  • 摘要: 目的 探讨G蛋白β3亚单位（GNB3）和血管紧张素Ⅰ转换酶（ACE）基因相互作用是否与子痫前期的发生有关联。方法 采用ACE基因PCR扩增片段长度多态性及GNB3基因限制性片段长度多态性方法，对成都地区汉族188例子痫前期及273例正常孕妇进行对照检测。结果 子痫前期及正常孕妇GNB3C825T和ACE I/D位点基因型和等位基因频率在两组之间差异无统计学意义（P>0.05），未见GNB3 C825T等位基因及ACEI/D相互作用与子痫前期发生的危险增加有关（OR 0.439~1.203，P均>0.05）。对联合基因型与血压水平关系的分析发现，正常对照组TT/II基因型携带者其舒张压水平增高〔（77.61±1.26） mmHg(1 mmHg=0.133 kPa)〕，且高于TT/ID〔（70.94±1.64） mmHg〕、CT/ID〔（73.15±0.89） mmHg〕和CT/DD〔（72.57±2.14） mmHg〕基因型携带者（P均P>0.05）。结论 本研究未发现GNB3基因C825T及ACE基因I/D位点的相互作用与中国人（成都地区）子痫前期发病有关联，但发现两基因的相互作用与正常孕妇舒张压水平有关。  
    Abstract: Objective To verify the hypothesis if interaction between the G protein β3 subunit (GNB3) C825T polymorphism and angiotensin-I converting enzyme (ACE) insertion/deletion (I/D) could lead to the increased risk of pre-eclampsia. Methods Analyses of ACEand GNB3genotypes were performed in 188 pre-eclamptic patients and 273 normal pregnant controls by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism in Chinese population, respectively. Results The distributions of alleles and genotypes for the GNB3C825T and ACE I/D polymorphisms were not found to be significantly associathed with pre-eclamptic status. No significant interaction of the influence of GNB3T allele and ACEgenotypes on the risk of pre-eclampsia was observed (OR 0.439-1.203, all P >0.05). However, we found that in homozygous 825T genotype carriers with the ACE II genotype in controls diastolic blood pressure (DBP) levels showed highest 〔(77.61±1.26） mmHg (1 mmHg=0.133 kPa)〕 among other three genotype combinations 〔TT/ID, （70.94±1.64） mmHg; CT/ID, （73.15±0.89） mmHg; CT/DD, （72.57±2.14） mmHg〕 (all P GNB3825T allele carriers with theACEI/D polymorphism in pre-eclampsia in Chinese population in Chengdu area. However there is the interaction of the two genes on DBP levels in pregnancy women without pre-eclampsia in the population.  
    • HTML全文
© 2015 《koko体育app 学报（医学版）》编辑部　版权所有 cc

开放获取✃ 本文遵循知识共享署名—非商业性使用4.0国际许可协议（CC BY-NC 4.0），允许第三方对本刊发表的论文自由共享（即在任何媒介以任何形式复制、发行原文）、演绎（即修改、转换或以原文为基础进行创作），必须给出适当的署名，提供指向本文许可协议的链接，同时标明是否对原文作了修改；不得将本文用于商业目的。CC BY-NC 4.0许可协议详情请访问

/

返回文章
返回
var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.src = "https://hm.baidu.com/hm.js?90c4d9819bca8c9bf01e7898dd269864"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); !function(p){"use strict";!function(t){var s=window,e=document,i=p,c="".concat("https:"===e.location.protocol?"https://":"http://","sdk.51.la/js-sdk-pro.min.js"),n=e.createElement("script"),r=e.getElementsByTagName("script")[0];n.type="text/javascript",n.setAttribute("charset","UTF-8"),n.async=!0,n.src=c,n.id="LA_COLLECT",i.d=n;var o=function(){s.LA.ids.push(i)};s.LA?s.LA.ids&&o():(s.LA=p,s.LA.ids=[],o()),r.parentNode.insertBefore(n,r)}()}({id:"K9y7iMpaU8NS42Fm",ck:"K9y7iMpaU8NS42Fm"}); koko体育-koko体育app koko体育-koko体育网页版koko体育app koko体育-全站app下载(官网) m6米乐app|下载 m6米乐app|主頁欢迎您!!