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肖桂荣, 徐珽. 2009~2013年koko体育app 华西医院1 998株丙型肝炎病毒基因分型研究[J]. koko体育app 学报(医学版), 2016, 47(5): 755-758.
引用本文: 肖桂荣, 徐珽. 2009~201两年多成都学校华西医院1 998株丙型慢性乙肝病菌dna临床表现科学研究[J]. 成都学校学报(医学专业版), 2016, 47(5): 755-758.
XIAO Gui-rong, XU TingY。. Genotype Distribution of 1 998 Strains of Hepatitis C Virus in West China Hospital of Sichuan University from2009 to 2013[J]. Journal of Sichuan University (Medical Sciences), 2016, 47(5): 755-758.
Citation: XIAO Gui-rong, XU TingY。. Genotype Distribution of 1 998 Strains of Hepatitis C Virus in West China Hospital of Sichuan University from2009 to 2013[J]. Journal of Sichuan University (Medical Sciences), 2016, 47(5): 755-758.

2009~2013年koko体育app 华西医院1 998株丙型肝炎病毒基因分型研究

Genotype Distribution of 1 998 Strains of Hepatitis C Virus in West China Hospital of Sichuan University from2009 to 2013

  • 摘要: 目的 了解koko体育app 华西医院近年来检测出的丙型肝炎病毒基因型分布特点。方法 收集2009年1月至2013年12月间在koko体育app 华西医院就诊的丙型肝炎病毒感染者的基因分型结果,分析基因型分布特征。结果 1 998例丙型肝炎病毒感染者中,共检出5种基因型、15种基因亚型,其中4例为2种基因亚型的混合感染。其基因型或亚型分布:1a型8例(0.40%)、1b型1 368例(68.47%)、1c型18例(0.90%)、2a型78例(3.90%)、2b型1例(0.05%)、2i型16例(0.80%)、3a型291例(14.56%)、3b型154例(7.71%)、3k型4例(0.20%)、5a型1例(0.05%)、6a型50例(2.50%)、6b型3例(0.15%)、6h型1例(0.05%)、6n型1例(0.05%),混合感染中1b/1c型、1b/6h型、2c/2a型、3b/3k型各1例(各占0.05%)。不同性别间主要基因亚型分布差异无统计学意义(P >0.05),不同年龄段间分布差异有统计学意义(P <0.05)。结论 koko体育app 华西医院就诊患者丙型肝炎病毒基因亚型主要为1b亚型,其次为3a、3b、2a、6a亚型,同时还存在1a、1c、2b、2i、3k、5a、6b、6h、6n、1b/1c、1b/6 h、2c/2a、3b/3k等单一或混合基因型,提示患者基因型存在多样性。  
    Abstract: Objective To investigate hepatitis C virus (HCV) genotype distribution detected in West China Hospital of Sichuan University. Methods We analyzed genotype distribution data on HCV infected patients who had information of HCV genotypes from January 2009 to December 2013 diagnosed in West China Hospital of Sichuan University. Results Five genotypes and 15 genetic subtypes of HCV were found among the 1 998 cases, and 4 of the patients were infected with mixed HCV subtype. Among those genotypes and genetic subtypes, genotype 1a was detected in 8 cases (0.40%), genotype 1b in 1 368 cases (68.47%), genotype 1c in 18 cases (0.90%), genotype 2a in 78 cases (3.90%), genotype 2b in 1 case (0.05%), genotype 2i in 16 cases (0.80%), genotype 3a in 291 cases (14.56%), genotype 3b in 154 cases (7.71%), genotype 3k in 4 cases (0.20%), genotype 5a in 1 case (0.05%), genotype 6a in 50 cases (2.50%), genotype 6b in 3 cases (0.15%), genotype 6h in 1 case (0.05%), genotype 6n in 1 case (0.05%), mixed-genotype 1b/1c in 1 case (0.05%), mixed-genotype 1b/6h in 1 case (0.05%), mixed-genotype 2c/2a in 1 case (0.05%), and mixed-genotype 3b/3k in 1 case (0.05%). The distribution of five main HCV genetic subtypes on gender had no statistical significance (P >0.05), and its distribution on people with different ages had statistical significance (P <0.05). Conclusion The major genotypes of HCV were 1b (predominant), 3a, 3b, 2a, 6a in patients diagnosed in West China Hospital of Sichuan University, with the existence of single-genotype 1a, 1c, 2b, 2i, 3k, 5a, 6b, 6h, 6n and mixed-genotype 1b/1c, 1b/6h, 2c/2a, 3b/3k, indicating the diversity of HCV genotype.  
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