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罗文, 谭群友, 熊华蓉, 等. 普鲁斯的明缓释片体外释放与体内吸收的相关性研究[J]. koko体育app 学报（医学版）, 2013, 44(1): 80-83.
引用本文: 罗文, 谭群友, 熊华蓉, 等. 普鲁斯的明缓控片身体之外尽情释放与身体里吸收率的关于性研发[J]. 杭州大学时学报（中医学版）, 2013, 44(1): 80-83.
LUO Wen, TAN Qun-you, XIONG Hua-rong, et al. Correlation Between in vitro Release and in vivo Absorption of Sustained-releasing Tablets of Neostigmine Bromide[J]. Journal of Sichuan University (Medical Sciences), 2013, 44(1): 80-83.
Citation: LUO Wen, TAN Qun-you, XIONG Hua-rong, et al. Correlation Between in vitro Release and in vivo💎 Absorption of Sustained-releasing Tablets of Neostigmine Bromide[J]. Journal of Sichuan University (Medical Sciences), 2013, 44(1): 80-83.

普鲁斯的明缓释片体外释放与体内吸收的相关性研究

Correlation Between in vitro Release and in vivo Absorption of Sustained-releasing Tablets of Neostigmine Bromide

  • 摘要: 目的 评价普鲁斯的明缓释片体外释放和体内吸收之间的相关性。 方法 以水为溶出介质,测定普鲁斯的明缓释片的体外释放度,采用高效液相色谱法测定兔单剂量口服普鲁斯的明缓释片或普通片后的血药浓度,分别以Loo-Riegelman法计算体内吸收分数Fa和反卷积分法计算输入函数R。 结果 以体外累计释放度Y与Fa和R建立的回归方程分别为:Fa=0.9298Y + 4.6074,r=0.9961;R=2.0163Y-11.242,r=0.9270。 结论 普鲁斯的明缓释片体外释放与体内吸收之间相关性良好。  
    Abstract: Objective To determine the correlation between in vitro release and in vivo absorption of sustained-releasing tablets of neostigmine bromide. Methods Water was used as dissolution medium to measured in vitro release of neostigmine bromide. After a single oral administration of 100 mg neostigmine bromide to rabbits, the plasma concentrations of neostigmine bromide in the rabbits were determined by HPLC. The compartment model and deconvolution method were employed to explain the in vitro-in vivo correlation. Results Using Y as cumulative in vitro release and Fa as percentage of absorption, the regression equation was established:Fa=0.9298Y+4.6074,r=0.9961. The input function of R=2.0163Y-11.242,r=0.9270. Conclusion The correlation between in vitro release and in vivo absorption of neostigmine bromide is good.  
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