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周运霞, 谭惠文, 余叶蓉. 华西医院住院糖尿病酮症患者的临床特征及变化趋势[J]. koko体育app 学报(医学版), 2013, 44(6): 950-953.
引用本文: 周运霞, 谭惠文, 余叶蓉. 华西医院住院费用高血压酮症朋友的临床检验特殊性及的总趋势分析[J]. 四川省大学专业学报(医学界版), 2013, 44(6): 950-953.
ZHOU Yun-xia, TAN Hui-wen, YU Ye-rong. Clinical Features and Epidemiological Trend of Diabetic Ketosis in Patients Admitted to West China Hospital[J]. Journal of Sichuan University (Medical Sciences), 2013, 44(6): 950-953.
Citation: ZHOU Yun-xia, TAN Hui-wen, YU Ye-rong. Clinical Features and Epidemiological Trend of Diabetic Ketosis in Patients Admitted to West China Hospital[J]. Journal of Sichuan University (Medical Sciences), 2013, 44(6): 950-953.

华西医院住院糖尿病酮症患者的临床特征及变化趋势

Clinical Features and Epidemiological Trend of Diabetic Ketosis in Patients Admitted to West China Hospital

  • 摘要: 目的 了解koko体育app 华西医院1997~2005年住院糖尿病酮症(DK)患者的临床特征以及变化趋势,为本地区DK的临床流行病学研究提供初步资料。方法 回顾性收集koko体育app 华西医院1997~2005年所有出院诊断中包含“糖尿病酮症(含酸中毒)”的各科患者的病历资料, 分析全部DK患者的临床资料及实验室检查数据。结果 1997~2005年间住院DK患者在糖尿病患者中的构成比以平均每年0.12%的速度增长。其中应激性酮症患者在DK患者中的构成比无明显变化,自发性酮症中1型糖尿病酮症(T1D-DK)患者在DK患者中的构成比以平均每年2.00%的速度下降,而肥胖伴自发性酮症(OB-DK)患者在DK患者中的构成比以平均每年2.27%的速度增加。OB-DK患者以男性居多,平均起病年龄大于T1D-DK患者,有糖尿病家族史者及合并高血压、高尿酸血症/痛风、血脂紊乱及脂肪肝者较多,而胰岛β细胞功能较T1D-DK患者好。结论 近年来OB-DK患者在DK患者中的构成比明显上升,其临床特征与T1D-DK患者迥异,OB-DK可能是2型糖尿病的一种亚型。  
    Abstract: Objective To evaluate the clinical features and epidemiological trend of diabetes ketosis (DK) in patients admitted to West China Hospital. Methods We reviewed medical records of diabetic patients with DK who were admitted to West China Hospital from 1997 to 2005. Their clinical and laboratory data were analysed with SAS 9.0. Results From 1997 to 2005, the proportion of diabetic patients with DK increased by 0.12% annually. The proportion of provoked DK patients (who had a clinically evident precipitating factor) in those with DK remained stable; whereas the proportion of T1D patients in those with DK declined by 2.00% annually and the proportion of ketosis prone obesity diabetes (KPD) in those with DK increased by 2.27% annually. The KPD patients displayed a striking male predominance (2.31∶1, male∶female) and were diagnosed at an older age compared with those with T1D 〔(46.3±12.9) yr. vs. (28.9±14.7) yr.〕. The KPD patients were more likely to have a strong family history of diabetes and a better β-cell function reserve, and be accompanied with dyslipidemia (52.7%), hypertension (23.3%), fatty liver (10.1%) and hyperuricemia/gout (8.5%) compared with those with T1D. Conclusion In recent years the proportion of KPD patients in the hospitalized DK patients is increasing. With different characteristics compared with typical T1D, KPD might belong to a subgroup of T2D.  
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