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热层析成像联合超声检查对乳腺癌功能形态学的初步研究
Breast Thermal Tomography and High Frequency Ultrasound Imaging in Predicting Breast Cancer: a Preliminary Study
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摘要: 目的 探讨热层析成像联合超声成像对乳腺癌的诊断效能。方法 对298例有乳腺肿块的患者分别进行乳腺超声与乳腺热层析成像检查，以病理诊断为金标准,判断热层析单独以及联合超声的诊断效能。 结果 病理诊断出良性病例196例，恶性病例102例。超声检查诊断良性129例，恶性169例，敏感度99.02%，特异度62.78%，受试者工作曲线下面积0.814；热层析成像诊断良性179例，恶性119例，敏感度83.33%、特异度83.16%,受试者工作曲线下面积0.830；联合诊断良性192例，恶性106例，敏感度83.33%，特异度89.79%，受试者工作曲线下面积0.866；热层析成像检查与超声检查的非劣效性检验差异具有统计学意义（P＜0.001)。 结论 热层析成像仪对乳腺癌的诊断效能不差于超声检查,热层析成像联合超声检查可提高乳腺癌诊断的特异度和准确度。Abstract: Objective To determine the clinical value of breast thermal tomography and high frequency ultrasound imaging in diagnosing breast cancer. Methods Breast thermal tomography and high frequency ultrasound imaging were performed in 298 patients with breast lumps. The results were compared with pathological diagnosis. Results The ultrasound imaging had a sensitivity, specificity and the area under the curve (AUC) of 99.02%, 62.78% and 0.814, respectively, compared with 83.33%, 83.16% and 0.830 of thermal tomography, for diagnosing breast cancer. The two imaging results showed statistical significance in the test of non-inferiority (P＜0.001). A combination of the two imaging results produced a sensitivity, specificity and AUC of 83.33%, 89.79% and 0.866, respectively. Conclusion Thermal tomography is not inferior to ultrasonography in detecting breast cancer. The two combined can improve specificity and accuracy of the diagnosis of breast cancer.
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