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Abstract: ObjectiveTo ivestigate the effect of daily walking number on clinical,inflammatory and nutritional indexes for patients with chronic kidney disease. Methods90 non-dialysis patients with chronic kidney disease were selected and randomly divided equally into three groups,for groups A,B and C. 30 patients for group A were asked for the number of daily walk should less than 5 000 steps,while group B patients were asked for 5 000-9 999 steps of walk and group C for more than 10 000 steps. Basic treatments were given for each group of patients and basic information,clinical,inflammatory and nutritional datas of patients were collected. Results87 patients with chronic kidney disease completed the study,with baseline data between group A,B,C （n=30，29，28） consistently. After 3 months of exercise,there were no significant changes on blood lipids,serum uric acid and parathyroid hormone (PTH) for three groups,with serum creatinine of three groups stably. However,in group C,hemoglobin,ferritin,transferrin saturation were found increased significantly (P<0.05). For nutritional indexes,increasing of albumin and prealbumin level were found in three groups,while significant differences were only found in group B and C (P<0.05) and group C increased most. There were no significant change on body mass index (BMI),upper arm skinfold thickness and SGA score in three groups. For inflammatory data,significant decrease of C-reactive protein (CRP) and interleukin-6 (IL-6) were only seen in group C (P<0.05). ConclusionWalking does not increase the burden of the kidney,but can improve the nutrition and clinical indicators of patients,reduce inflammation.