koko体育app

欢迎来到《koko体育app 学报（医学版）》
何娟, 蔡扬. 口腔扁平苔藓病损区STAT1和IFN-γ的表达[J]. koko体育app 学报（医学版）, 2014, 45(1): 70-73.
引用本文: 何娟, 蔡扬. 牙齿圆形苔藓病损区STAT1和IFN-γ的呈现[J]. 云南高中学报（医疗版）, 2014, 45(1): 70-73.
HE Juan, CAI Yang. The Over-expression of STAT1 and IFN-γ in Lesions of Human Oral Lichen Planus[J]. Journal of Sichuan University (Medical Sciences), 2014, 45(1): 70-73.
Citation: HE Juan, CAI Yang. The Over-expression of STAT1 and IFN-γ in Lesions of Human Oral Lichen Planus[J]. Journal of Sichuan University (Medical Sciences), 2014, 45(1): 70-73.

口腔扁平苔藓病损区STAT1和IFN-γ的表达

The Over-expression of STAT1 and IFN-γ in Lesions of Human Oral Lichen Planus

  • 摘要: 目的 探讨信号转导与转录激活因子1（STAT1)、干扰素-γ(IFN-γ)在口腔扁平苔藓(OLP）病损发生发展中的作用。方法 48例OLP及10例正常口腔黏膜石蜡包埋组织，采用免疫组化SABC法检测相应组织中STAT1和IFN-γ蛋白的表达情况，分析其与OLP患者临床病理特征的相关性。结果 ①STAT1、IFN-γ 在OLP病损区表达阳性率均高于正常对照组，差异有统计学意义(Pχ2＝5.042，Pr=0.324, Pχ2=5.077，Pr=-0.388, P<0.05）。结论 OLP局部组织中存在STAT1和IFN-γ蛋白高表达，IFN-γ/STAT1通路在OLP局部病损形成过程中起到推动作用。  
    Abstract: Objective?To understand the possible role of signal transducer and activator of transcription 1 (STAT1) and interferon-γ (IFN-γ) in the generation of local lesions of oral lichen planus (OLP). Methods?Formalin-fixed, paraffin-embedded tissues of 10 cases of normal oral epithelium and 48 cases of OLP were investigated for STAT1 and IFN-γ proteins by using immunohistochemistry SABC method. The correlation between the expression of STAT1 and IFN-γ proteins and the clinical and pathological characteristics in OLP were statistically analyzed. Results ① STAT1 and IFN-γ were over expressed compared with healthy oral mucosa (Pχ2=5.042，?Pr=0.324, Pχ2=5.077, Pr=-0.388, P<0.05). Conclusion?The over-expression of STAT1 and IFN-γ may participate in the generation of local pathological damnification of OLP at the early stage.  
    • HTML全文
© 2014 《koko体育app 学报（医学版）》编辑部　版权所有 cc

开放获取ꦆ 本文遵循知识共享署名—非商业性使用4.0国际许可协议（CC BY-NC 4.0），允许第三方对本刊发表的论文自由共享（即在任何媒介以任何形式复制、发行原文）、演绎（即修改、转换或以原文为基础进行创作），必须给出适当的署名，提供指向本文许可协议的链接，同时标明是否对原文作了修改；不得将本文用于商业目的。CC BY-NC 4.0许可协议详情请访问

/

返回文章
返回
var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.src = "https://hm.baidu.com/hm.js?90c4d9819bca8c9bf01e7898dd269864"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); !function(p){"use strict";!function(t){var s=window,e=document,i=p,c="".concat("https:"===e.location.protocol?"https://":"http://","sdk.51.la/js-sdk-pro.min.js"),n=e.createElement("script"),r=e.getElementsByTagName("script")[0];n.type="text/javascript",n.setAttribute("charset","UTF-8"),n.async=!0,n.src=c,n.id="LA_COLLECT",i.d=n;var o=function(){s.LA.ids.push(i)};s.LA?s.LA.ids&&o():(s.LA=p,s.LA.ids=[],o()),r.parentNode.insertBefore(n,r)}()}({id:"K9y7iMpaU8NS42Fm",ck:"K9y7iMpaU8NS42Fm"}); koko体育-koko体育app koko体育-koko体育网页版koko体育app koko体育-全站app下载(官网) m6米乐app|下载 m6米乐app|主頁欢迎您!!