koko体育app

欢迎来到《koko体育app 学报（医学版）》
蒋瑜, 杨太珠, 王婧等. 妊娠11+0～13+6周胎儿颌面角对胎儿染色体非整倍体异常诊断价值的研究[J]. koko体育app 学报（医学版）, 2018, 49(5): 812-814.
引用本文: 蒋瑜, 杨太珠, 王婧等. 早期妊娠11+0～13+6周宝宝颌面角对宝宝染色剂体非整倍体失败诊断仪價值的设计[J]. 杭州二本大学学报（医疗版）, 2018, 49(5): 812-814.
JIANG Yu, YANG Tai-zhu, WANG Jing. et al. Value of Fetal Frontomaxillary Facial Angle in Diagnosing Fetal Chromosomal Aneuploidy at 11+0 to 13+6 Weeks of Gestation[J]. Journal of Sichuan University (Medical Sciences), 2018, 49(5): 812-814.
Citation: JIANG Yu, YANG Tai-zhu, WANG Jing. et al. Value of Fetal Frontomaxillary Facial Angle in Diagnosing Fetal Chromosomal Aneuploidy at 11+0 to 13+6 Weeks of Gestation[J]. Journal of Sichuan University (Medical Sciences), 2018, 49(5): 812-814.

妊娠11+0～13+6周胎儿颌面角对胎儿染色体非整倍体异常诊断价值的研究

Value of Fetal Frontomaxillary Facial Angle in Diagnosing Fetal Chromosomal Aneuploidy at 11+0 to 13+6 Weeks of Gestation

  • 摘要: 目的 探讨妊娠11+0～13+6周胎儿颌面角对胎儿染色体非整倍体异常的诊断价值。方法 随机选取2015年1月至2016年8月在我院行胎儿颈项透明层厚度（NT）检查的单胎妊娠胎儿（妊娠11+0～13+6周），测量胎儿的头臀长（CRL）、NT和颌面角（FMFA）。随访胎儿的染色体检查结果。比较染色体整倍体胎儿与非整倍体胎儿的FMFA是否存在差异。采用线性回归分析评价染色体整倍体胎儿FMFA与CRL是否具有相关性。采用受试者工作特征曲线（ROC曲线）评估FMFA测量对于识别胎儿染色体非整倍体异常的诊断价值。结果 染色体整倍体胎儿FMFA为80.61°（79.94°～81.28°），非整倍体胎儿FMFA为91.24°(90.21°～92.25°)；染色体整倍体胎儿NT为1.63 mm（0.90～2.43 mm），非整倍体胎儿NT为4.18 mm（3.12～5.44 mm）。染色体整倍体胎儿与非整倍体胎儿之间FMFA及NT的差异均有统计学意义（Py=－0.320 8x+100.32）。ROC曲线的曲线下面积为0.960，当FMFA为87.5°时，FMFA诊断胎儿染色体非整倍体异常的敏感性为90.5%，特异性为94.3%。结论 妊娠11+0～13+6周，染色体非整倍体胎儿的FMFA明显大于整倍体胎儿；FMFA对胎儿染色体非整倍体异常具有较大的诊断价值。  
    Abstract: Objective To determine the value of fetal Frontomaxillary facial angle (FMFA) in diagnosing chromosomal aneuploidy at 11+0-13+6 weeks of pregnancy. Methods Singleton pregnancies were randomly selected from January 2015 to August 2016 in our hospital. The crown-rump length (CRL), nuchal translucency (NT) and FMFA of the fetuses were measured and recorded, followed by chromosomal tests. FMFA and NT of the euploid fetuses were compared with those of the aneuploidy fetuses. A linear regression model was established between FMFA and CRL. The specificity and sensitivity of FMFA for diagnosing aneuploidy were assessed using the receiver operating characteristic (ROC) curve. Results The euploid fetuses had 80.61° (79.94°-81.28°) FMFA, compared with 91.24° (90.21°-92.25°) in the aneuploidy fetuses. The euploid fetuses had 1.63 mm (0.90-2.43 mm) NT, compared with 4.18 mm (3.12-5.44 mm) NT in the aneuploid fetuses. The differences were statistically significant (Py=－0.320 8x+100.32）. FMFA had a sensitivity of 90.5% and a specificity of 94.3% for diagnosing chromosomal aneuploidy with a cut-off value of 87.5° and 0.960 of the area under the curve. Conclusion Aneuploid fetuses have significantly greater FMFA than euploid fetuses at 11+0 to 13+6 weeks of gestation.  
    • HTML全文
© 2018 《koko体育app 学报（医学版）》编辑部　版权所有 cc

开放获取🍨 本文遵循知识共享署名—非商业性使用4.0国际许可协议（CC BY-NC 4.0），允许第三方对本刊发表的论文自由共享（即在任何媒介以任何形式复制、发行原文）、演绎（即修改、转换或以原文为基础进行创作），必须给出适当的署名，提供指向本文许可协议的链接，同时标明是否对原文作了修改；不得将本文用于商业目的。CC BY-NC 4.0许可协议详情请访问

/

返回文章
返回
var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.src = "https://hm.baidu.com/hm.js?90c4d9819bca8c9bf01e7898dd269864"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); !function(p){"use strict";!function(t){var s=window,e=document,i=p,c="".concat("https:"===e.location.protocol?"https://":"http://","sdk.51.la/js-sdk-pro.min.js"),n=e.createElement("script"),r=e.getElementsByTagName("script")[0];n.type="text/javascript",n.setAttribute("charset","UTF-8"),n.async=!0,n.src=c,n.id="LA_COLLECT",i.d=n;var o=function(){s.LA.ids.push(i)};s.LA?s.LA.ids&&o():(s.LA=p,s.LA.ids=[],o()),r.parentNode.insertBefore(n,r)}()}({id:"K9y7iMpaU8NS42Fm",ck:"K9y7iMpaU8NS42Fm"}); koko体育-koko体育app koko体育-koko体育网页版koko体育app koko体育-全站app下载(官网) m6米乐app|下载 m6米乐app|主頁欢迎您!!