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郭琴, 罗薇, 银代淑等. 体检人群尿微量白蛋白肌酐比的临床意义[J]. koko体育app 学报(医学版), 2016, 47(1): 122-127.
引用本文: 郭琴, 罗薇, 银代淑等. 休检年龄段尿微量分析白血清肌酐比的诊疗目的[J]. 北京师范大学学报(分子生物学版), 2016, 47(1): 122-127.
GUO Qin, LUO Wei, YIN Dai-shu. et al. Clinical Significance of Urinary Microalbumin to Creatinine Ratio in Physical Examinations[J]. Journal of Sichuan University (Medical Sciences), 2016, 47(1): 122-127.
Citation: GUO Qin, LUO Wei, YIN Dai-shu. et al. Clinical Significance of Urinary Microalbumin to Creatinine Ratio in Physical Examinations[J]. Journal of Sichuan University (Medical Sciences), 2016, 47(1): 122-127.

体检人群尿微量白蛋白肌酐比的临床意义

Clinical Significance of Urinary Microalbumin to Creatinine Ratio in Physical Examinations

  • 摘要: 目的 探讨尿微量白蛋白肌酐比(mALB/Cr)在体检人群中的分布特征及其与相关代谢指标的关系。方法 收集2013年11月至2014年10月我院体检中心体检项目包括尿mALB/Cr的4 184例体检者的体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、腰围、臀围、腰臀比(WHR)、尿mALB/Cr及血糖(GLU)、血脂〔总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)〕、肾功能〔尿素氮(BUN)、血肌酐(SCr)、尿酸(UA)、血清胱抑素C(Cys-C)、估计肾小球滤过率(eGFR)〕、同型半胱氨酸(Hcy)等结果,分析尿mALB/Cr在体检人群中的分布特征,尿mALB/Cr与相关代谢指标的关系,微量白蛋白尿(MAU)发生的独立危险因素。结果 ①4 184例纳入分析的体检者的尿mALB/Cr 中位数(四分位间距)为5.7(3.1~11.8) mg/g,其中男性5.4(3.0~11.3) mg/g,女性6.3(3.6~13.2) mg/g,男女性别间差异有统计学意义(P<0.05)。②体检者尿mALB/Cr总阳性率(mALB/Cr ≥30 mg/g为阳性)为10.95%,其中男性10.96%,女性10.90%,男女性别间差异无统计学意义(P>0.05)。③尿mALB/Cr中位数与阳性率均随着年龄增加而升高。④按mALB/Cr<30 mg/g、30~300 mg/g、>300 mg/g分为正常、微量白蛋白尿、显性白蛋白尿3组,3组体检者间的年龄、BMI、SBP、DBP、腰围、WHR、GLU、HDL-C、TG、SCr、BUN、UA、eGFR、Cys-CR的差异均有统计学意义(P<0.05)。⑤Logistic多元回归分析显示年龄、SBP、WHR、GLU、TG的增加及eGFR的降低是微量白蛋白尿发生的独立危险因素。结论 体检人群中尿mALB/Cr异常率较高,年龄、血压、血糖、血脂升高及肾功能下降均可增加微量白蛋白尿发生的风险,应加强对高代谢综合征及中老年人群的尿mALB/Cr检测。  
    Abstract: Objective To determine the association between urinary microalbumin to creatinine ratio (mALB/Cr) and metabolic indicators in people undergoing physical examinations. Methods A total of 4 184 people who took physical examinations in West China Hospital, Sichuan University from November 2013 to October 2014 participated in this study. We measured their body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), waistline, hipline, Waist-to-hip ratio (WHR), urinary mALB/Cr, serum glucose (GLU), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), blood urea nitrogen (BUN), serum creatinine (SCr), uric acid (UA), cystatin C (Cys-C), glomerular filtration rate (eGFR) and homocysteine (Hcy). Results ① The participants had a median (interquartile range) mALB/Cr of 5.7 (3.1-11.8) mg/g: 5.4 (3.0-11.3) mg/g for males and 6.3 (3.6-13.2) mg/g for females (P<0.05). ② About 10.95% participants (10.96% for males and 10.90% for females) had a mALB/Cr ≥30 mg/g. ③ mALB/Cr increased with age. ④ BMI, SBP, DBP, waistline, WHR, GLU, HDL-C, TG, SCr, BUN, UA, eGFR and Cys-C were associated the distribution of participants (P<0.05) across the three groups of mALB/Cr: normal (<30 mg/g), microalbuminuria (30-300 mg/g), and proteinuria (>300 mg/g). ⑤ Logistic regression demonstrated that age, SBP, WHR, GLU, TG and eGFR were significant predictors of albuminuria. Conclusion A high level of abnormal/positive mALB/Cr was found in people undergoing physical examinations. Increased age, SBP, WHR, GLU, TG and decreased eGFR are major risk factors of abnormal mALB/Cr. mALB/Cr should be monitored, especially in the elderly and those with high-metabolic-syndrome.  
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