超声联合微泡造影在分子影像诊断及治疗中的研究进展

邱逦; 冷钱英; 罗燕

超声联合微泡造影在分子影像诊断及治疗中的研究进展

Progress of Ultrasound Microbubble Contrast Technology in the Diagnosis and Treatment of Clinical Diseases

摘要

摘要: 超声造影技术是近十年来超声医学的重要发展方向，是超声发展史上的第三次革命。超声造影(contrast-enhanced ultrasound，CEUS)在临床上已应用于包括肾脏、甲状腺、乳腺等多个器官疾病的诊断，大大提高了超声诊断的准确性，靶向微泡的出现更为超声分子影像提供了可能。微泡造影剂也是一种有效的药物或基因载体，通过局部超声辐照破坏微泡，实现药物或基因的定位释放，可以达到靶向治疗的目的。关注超声联合微泡造影在基础研究及临床中的进展，提高研究级临床认识水平，必定能促进超声微泡造影更多、更好的应用。

Abstract: Contrast enhanced ultrasound (CEUS) technology has made important developments over the past decade. It has been applied in the clinical diagnosis for various diseases of multiple organs including liver, kidney, thyroid, breast and so on, which greatly improves the accuracy of ultrasound diagnosis. The emergence of targeted ultrasound microbubble makes ultrasound molecular imaging possible. More than the improvement of ultrasound imaging, microbubble contrast agent also could be an effective drug or gene carrier. Microbubble will rupture under the irradiation effect of local ultrasound, and then the carried drugs or genes will be released to achieve the purpose of targeted therapy. We should pay more attention on the progress of ultrasound microbubble contrast technology in clinical and basic research. It will promote better understanding and clinical applications of this novel medical ultrasound technology.

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