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彭昌兵, 徐锐, 肖硕萌等. IFRD1基因rs3807213位点基因多态性与胃癌关系的研究[J]. koko体育app 学报（医学版）, 2014, 45(1): 49-52.
引用本文: 彭昌兵, 徐锐, 肖硕萌等. IFRD1遗传dnars3807213位点遗传dna多态性与胃溃疡相关的设计[J]. 江苏大学专业学报（中医学版）, 2014, 45(1): 49-52.
PENG Chang-bing, XU Rui, XIAO Shuo-meng.et al. Relationship of IFRD1-rs3807213 Gene Polymorphism with the Risk of Gastric Cancer among Chinese[J]. Journal of Sichuan University (Medical Sciences), 2014, 45(1): 49-52.
Citation: PENG Chang-bing, XU Rui, XIAO Shuo-meng.et al. Relationship of IFRD1-rs3807213 Gene Polymorphism with the Risk of Gastric Cancer among Chinese[J]. Journal of Sichuan University (Medical Sciences), 2014, 45(1): 49-52.

IFRD1基因rs3807213位点基因多态性与胃癌关系的研究

Relationship of IFRD1-rs3807213 Gene Polymorphism with the Risk of Gastric Cancer among Chinese

  • 摘要: 目的 探讨干扰素相关发育调节蛋白1 （IFRD1）基因rs3807213位点基因多态性与中国汉族人胃癌发生的关系。方法 采用病例-对照研究方法，以53例胃癌患者为病例组，50例健康人为对照组。采集外周血，提取全血DNA，再采用聚合酶链反应 （polymerase chain reaction,PCR）扩增DNA后，对IFRD1基因rs3807213位点进行测序，分析3个基因型 （AA，AC，CC）在病例组和对照组之间的分布差异，并研究其与胃癌风险及临床病理分期的关系。结果 病例组内rs3807213位点C等位基因频率高于对照组 （OR值为3.759，95%CI为1.521～9.294；P=0.003）。与对照组相比，胃癌患者具有更高频率的rs3807213位点CC基因型 （OR值为4.028，95%CI为1.513～10.720；P=0.004）。将病例组按病理分期进行分组分析，rs3807213位点各基因型及等位基因频率的组间差异均无统计学意义 （P>0.05）。结论 IFRD1基因rs3807213位点基因多态性可能与中国汉族人胃癌发生有关，但与胃癌的病理分期无关。  
    Abstract: Objective?To investigate the association between rs3807213 gene polymorphism in interferon-related developmental regulator 1 gene（IFRD1） and the risk of gastric cancer among Chinese. Methods?There were 53 gastric cancer patients and 50 healthy people included in this case-control study. The blood samples were collected from each observed object and genotype (AA，AC，CC) of IFRD1 rs3807213 SNP was detected after polymerase chain reaction (PCR). The relationships of rs3807213 gene polymorphism with gastric cancer risk, clinic and pathologic features were analyzed. Results?Patients with stomach cancer had a significantly higher frequency of rs3807213 C allele distributions （OR=3.759，95%CI=1.521-9.294；P=0.003） than the controls. Compared with control group, patients with gastric cancer had a significantly higher frequency of rs3807213 CC genotype（OR=4.028，95%CI=1.513-10.720；P=0.004）. When stratified by pathological stage of gastric cancer, there was no significant difference observed. Conclusion?IFRD1-rs3807213 polymorphism may be associated with the increased risk of gastric cancer.  
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