摘要:
肿瘤微环境包括肿瘤相关的各种细胞和非细胞组分,其在肿瘤发生、生长和转移的过程中起着非常重要的作用。长链非编码RNA(long noncoding RNA, lncRNA)是一类长度超过200 nt的非编码RNA,参与多种生理和病理进程。研究表明,lncRNA在肿瘤与其微环境相互作用中起重要作用,进而影响肿瘤进展。本文将近年来关于肿瘤微环境中lncRNA的研究进展进行了总结,并探讨其在肿瘤早期诊断和治疗中的应用前景,提出开发有效特异性敲除lncRNA的策略和选择合适的体内运载工具特异性靶向目的细胞等方面是未来深入探索的方向。
Abstract:
Tumor microenvironment incorporates various tumor-related cellular and non-cellular components, playing a crucial role in the process of the pathogenesis, growth, and metastasis of tumors. Long noncoding RNA (lncRNA), a kind of noncoding RNA with a length of more than 200 nt, participates in a variety of physiological and pathological processes. Recent studies have shown that lncRNA plays a vital role in the interaction between tumors and the tumor microenvironment, thereby affecting tumor progression. Herein, we reviewed the research progress on the lncRNA in tumor microenvironment, discussed the potential application of lncRNA in early diagnosis and treatment of tumors, and suggested that some issues should be further explored in future research, including developing effective strategies for knocking out specific lncRNA and selecting appropriate in vivo delivery vehicles targeting specific cells.