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邓丽红, 魏巍, 乔春霞, 等. 首发未服药精神分裂症患者自发脑活动的频率特异性改变[J]. koko体育app 学报（医学版）, 2023, 54(2): 281-286. DOI:
引用本文: 邓丽红, 魏巍, 乔春霞, 等. 首发未服药精神分裂症患者自发脑活动的频率特异性改变[J]. koko体育app 学报（医学版）, 2023, 54(2): 281-286. DOI:
DENG Li-hong, WEI Wei, QIAO Chun-xia, et al. Frequency-Specific Alterations of Spontaneous Brain Activity in First-Episode Drug-Naïve Schizophrenia[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(2): 281-286. DOI:
Citation: 🐭 DENG Li-hong, WEI Wei, QIAO Chun-xia, et al. Frequency-Specific Alterations of Spontaneous Brain Activity in First-Episode Drug-Naïve Schizophrenia[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(2): 281-286. DOI:

首发未服药精神分裂症患者自发脑活动的频率特异性改变

Frequency-Specific Alterations of Spontaneous Brain Activity in First-Episode Drug-Naïve Schizophrenia

  • 摘要:
      目的  探究首发未服药精神分裂症（schizophrenia, SZ）患者自发脑活动的频率特异性改变及其与临床症状的关联。
      方法  采集84例首发未服药SZ患者和94例健康对照的静息态功能磁共振数据，计算slow-2、slow-3、slow-4和slow-5频段的低频振幅（ALFF）和局部一致性（ReHo）。用两独立样本t检验比较ALFF和ReHo的组间差异。用偏相关分析探索SZ组异常ALFF和ReHo与临床症状严重程度的相关性。
      结果  与健康对照相比，SZ组在slow-2、slow-3和slow-4频段小脑上部和蚓部ALFF降低，在slow-4频段左侧颞上回、颞中回和上颞极ALFF增高；在slow-3频段右侧中央后回和中央前回ReHo下降。SZ组slow-4频段的左侧颞上回、颞中回和上颞极ALFF与阳性与阴性症状量表兴奋因子分呈正相关趋势。
      结论  首发未服药SZ患者局部自发脑活动异常具有频率特异性。
     
    Abstract:
      Objective  To investigate frequency-specific alterations of spontaneous brain activity in first-episode drug-naïve schizophrenia (SZ) patients and the associations with clinical symptoms.
      Methods  We collected the resting-state functional MRI (rs-fMRI) data from 84 first-episode drug-naïve SZ patients and 94 healthy controls (HCs) and calculated the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) of four frequency bands, including slow-2, slow-3, slow-4, and slow-5. Two-sample t-tests were used to evaluate the intergroup differences in ALFF and ReHo, while partial correlation analyses were conducted to explore the associations between abnormal ALFF and ReHo and the severity of clinical symptoms in the SZ group.
      Results  Compared with HCs, the SZ group showed reduced ALFF in superior cerebellum and cerebellar vermis across slow-2, slow-3, and slow-4 bands, while increased ALFF was found in left superior temporal gyrus, middle temporal gyrus, and superior temporal pole at slow-4 band. Moreover, reduced ReHo was observed in the right precentral and postcentral gyri at slow-3 band in the SZ group. Additionally, the ALFF of left superior temporal gyrus, middle temporal gyrus, and superior temporal pole in slow-4 band showed a trend of positive correlation with the excited factor score of Positive and Negative Syndrome Scale (PANSS) in the SZ group.
      Conclusion  Our results suggest that local alterations of spontaneous brain activity were frequency-specific in first-episode drug-naïve SZ patients.
     
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