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张伟, 马骁, 程浩, 等. 高糖饮食与炎症性疾病研究进展[J]. koko体育app 学报（医学版）, 2022, 53(3): 538-542. DOI:
引用本文: 张伟, 马骁, 程浩, 等. 高糖饮食与炎症性疾病研究进展[J]. koko体育app 学报（医学版）, 2022, 53(3): 538-542. DOI:
ZHANG Wei, MA Xiao, CHENG Hao, et al. Research Progress in High-Sugar Diet and Inflammatory Diseases[J]. Journal of Sichuan University (Medical Sciences), 2022, 53(3): 538-542. DOI:
Citation: ♋ ZHANG Wei, MA Xiao, CHENG Hao, et al. Research Progress in High-Sugar Diet and Inflammatory Diseases[J]. Journal of Sichuan University (Medical Sciences), 2022, 53(3): 538-542. DOI:

高糖饮食与炎症性疾病研究进展

Research Progress in High-Sugar Diet and Inflammatory Diseases

  • 摘要: 高糖饮食会引起胰岛素耐受、糖尿病和非酒精性脂肪肝等多种疾病。近年来，随着对高糖饮食相关研究的深入，研究者们陆续发现和阐明了其对自身免疫性疾病和感染性疾病等炎症性疾病的影响。本综述通过总结目前关于高糖饮食与炎症性疾病相关的研究进展，指出以高葡萄糖和高果糖摄入为代表的高糖饮食可能是慢性炎症性疾病恶化的重要诱导因素，并归纳了高糖饮食导致炎症性疾病恶化的调控机制。笔者认为，开展广泛的临床研究和真实世界研究，并深入揭示高葡萄糖饮食和高果糖饮食在免疫调节中的差异性，是未来的重点研究方向和亟待解决的关键科学问题。  
    Abstract: High-sugar diet causes various diseases, including insulin resistance, diabetes, and non-alcoholic fatty liver disease (NAFLD). In recent years, as researchers probe deeper and deeper into issues concerning high-sugar diet, the impact of high-sugar diet on inflammatory diseases such as autoimmune diseases and infectious diseases has been gradually uncovered and clarified. In this review, we summarized the current research progress on high-sugar diet and inflammatory diseases, and suggested that a high-sugar diet based on high intake of glucose and fructose may be an important factor inducing the exacerbation of chronic inflammatory diseases such as autoimmune diseases. Moreover, we also summarized the regulatory mechanisms through which high-sugar diet induces exacerbation of inflammatory diseases. In addition, we stated that conducting extensive clinical research and research in real-life settings and pursuing thorough investigation to reveal the different involvement of high-glucose diet and high-fructose diet in immune regulation are the key scientific issues that need urgent solutions in the future.  
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