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周铎, 杨德琴. miRNA通过靶向骨保护素参与多种疾病的发病机制[J]. koko体育app 学报(医学版), 2024, 55(3): 777-782. DOI:
引用本文: 周铎, 杨德琴. miRNA通过靶向骨保护素参与多种疾病的发病机制[J]. koko体育app 学报(医学版), 2024, 55(3): 777-782. DOI:
ZHOU Duo, YANG Deqin. miRNA Is Involved in the Pathogenesis of Multiple Diseases by Targeting Osteoprotegerin[J]. Journal of Sichuan University (Medical Sciences), 2024, 55(3): 777-782. DOI:
Citation: ZHO🦩U Duo, YANG Deqin. miRNA Is Involved in the Pathogenesis of Multiple Diseases by Targeting Osteoprotegerin[J]. Journal of Sichuan University (Medical Sciences), 2024, 55(3): 777-782. DOI:

miRNA通过靶向骨保护素参与多种疾病的发病机制

miRNA Is Involved in the Pathogenesis of Multiple Diseases by Targeting Osteoprotegerin

  • 摘要: 骨保护素(osteoprotegerin, OPG)是肿瘤坏死因子受体家族中的一员,在成人肺、心脏、肾脏、肝脏、脾脏、胸腺、前列腺、卵巢、小肠、甲状腺、淋巴结、气管、肾上腺、睾丸和骨髓中都有高度的表达,与核因子κB受体激活剂(receptor activator of nuclear factor-κB, RANK)及核因子κB受体激活剂配体(receptor activator of nuclear factor-κB ligand, RANKL)共同组成RANK/RANKL/OPG途径,在多种疾病发展的分子机制中起着重要的作用。微小RNAs(microRNAs, miRNA)是在真核生物中的一类内源性的具有调控功能的非编码RNA,其大小约20~25个核苷酸。miRNA基因被RNA聚合酶转录成初级转录物,与RNA诱导的沉默复合体结合,通过碱基互补配对的方式识别靶mRNA,单个miRNA可以靶向数百个mRNA,并通过参与功能相互作用的途径影响许多基因的表达。近年来大量研究通过miRNA分离、miRNA定量、miRNA谱分析、miRNA靶点检测、体外和体内调节miRNA水平等技术探究了miRNA在疾病中的作用机制,并发现miRNA可通过靶向OPG在骨质疏松症、类风湿关节炎等多种疾病发病中发挥关键作用。本综述旨在探讨各种疾病中miRNA与OPG的相互作用,为研究OPG在疾病中的作用机制提出新的思路。  
    Abstract: As a member of the tumor necrosis factor receptor family, osteoprotegerin (OPG) is highly expressed in adults in the lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestines, thyroid gland, lymph nodes, trachea, adrenal gland, the testis, and bone marrow. Together with the receptor activator of nuclear factor-κB (RANK) and the receptor activator of nuclear factor-κB ligand (RANKL), it forms the RANK/RANKL/OPG pathway, which plays an important role in the molecular mechanism of the development of various diseases. MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs performing regulatory functions in eukaryotes, with a size of about 20-25 nucleotides. miRNA genes are transcribed into primary transcripts by RNA polymerase, bind to RNA-induced silencing complexes, identify target mRNAs through complementary base pairing, with a single miRNA being capable of targeting hundreds of mRNAs, and influence the expression of many genes through pathways involved in functional interactions. In recent years, a large number of studies have been done to explore the mechanism of action of miRNA in diseases through miRNA isolation, miRNA quantification, miRNA spectrum analysis, miRNA target detection, in vitro and in vivo regulation of miRNA levels, and other technologies. It was found that miRNA can play a key role in the pathogenesis of osteoporosis, rheumatoid arthritis, and other diseases by targeting OPG. The purpose of this review is to explore the interaction between miRNA and OPG in various diseases, and to propose new ideas for studying the mechanism of action of OPG in diseases.  

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