koko体育app

欢迎来到《koko体育app 学报(医学版)》
李雨含, 王瑗, 袁泉. α-酮戊二酸在代谢综合征中的研究进展[J]. koko体育app 学报(医学版), 2024, 55(3): 783-792. DOI:
引用本文: 李雨含, 王瑗, 袁泉. α-酮戊二酸在代谢综合征中的研究进展[J]. koko体育app 学报(医学版), 2024, 55(3): 783-792. DOI:
LI Yuhan, WANG Yuan, YUAN Quan. Latest Findings on the Role of α-Ketoglutarate in Metabolic Syndrome[J]. Journal of Sichuan University (Medical Sciences), 2024, 55(3): 783-792. DOI:
Citation: LI Yuha꧒n, WAN﷽G Yuan, YUAN Quan. Latest Findings on the Role of α-Ketoglutarate in Metabolic Syndrome[J]. Journal of Sichuan University (Medical Sciences), 2024, 55(3): 783-792. DOI:

α-酮戊二酸在代谢综合征中的研究进展

Latest Findings on the Role of α-Ketoglutarate in Metabolic Syndrome

  • 摘要: α-酮戊二酸(alpha-ketoglutarate, α-KG)是三羧酸循环的内源性中间代谢产物,参与多种细胞代谢途径,作为能量供体、氨基酸前体、表观遗传调控因子发挥作用。α-KG还具有免疫调控、缓解氧化应激、延缓衰老等生理功能。近年来,研究发现体内α-KG水平与代谢综合征,如肥胖和高血糖等病理因素密切相关。外源性补充α-KG可以改善代谢综合征相关的肥胖程度、血糖水平以及心血管疾病风险等,同时参与调节代谢综合征共同的病理机制,提示α-KG在代谢综合征中的潜在应用价值。本文以α-KG和代谢综合征为主题,结合最新研究发现,综述α-KG在改善代谢综合征的病理发生和疾病发展等方面的研究动态,为进一步探究α-KG在代谢综合征中的应用提供理论基础。未来研究或围绕代谢综合征的共同致病机理,研究α-KG能否实现代谢综合征的“异病同治”的治疗目标。  
    Abstract: Alpha-ketoglutarate (α-KG), an endogenous intermediate of the tricarboxylic acid cycle, is involved in a variety of cellular metabolic pathways. It serves as an energy donor, a precursor of amino acid biosynthesis, and an epigenetic regulator. α-KG plays physiological functions in immune regulation, oxidative stress, and anti-aging as well. In recent years, it has been reported that the level of α-KG in the body is closely associated with metabolic syndrome, including obesity, hyperglycemia, and other pathological factors. Exogenous supplementation of α-KG improves obesity, blood glucose levels, and cardiovascular disease risks associated with metabolic syndrome. Furthermore, α-KG regulates the common pathological mechanisms of metabolic syndrome, suggesting the potential application prospect of α-KG in metabolic syndrome. In order to provide a theoretical basis for further exploration of the application of α-KG in metabolic syndrome, we focused on α-KG and metabolic syndrome in this article and summarized the latest research progress in the role of α-KG in improving the pathological condition and disease progression of metabolic syndrome. For the next step, researchers may focus on the co-pathogenesis of metabolic syndrome and investigate whether α-KG can be used to achieve the therapeutic goal of "homotherapy for heteropathy" in the treatment of metabolic syndrome.  

/

koko体育app: 返回文章
koko体育app:返回
var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.src = "https://hm.baidu.com/hm.js?90c4d9819bca8c9bf01e7898dd269864"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); !function(p){"use strict";!function(t){var s=window,e=document,i=p,c="".concat("https:"===e.location.protocol?"https://":"http://","sdk.51.la/js-sdk-pro.min.js"),n=e.createElement("script"),r=e.getElementsByTagName("script")[0];n.type="text/javascript",n.setAttribute("charset","UTF-8"),n.async=!0,n.src=c,n.id="LA_COLLECT",i.d=n;var o=function(){s.LA.ids.push(i)};s.LA?s.LA.ids&&o():(s.LA=p,s.LA.ids=[],o()),r.parentNode.insertBefore(n,r)}()}({id:"K9y7iMpaU8NS42Fm",ck:"K9y7iMpaU8NS42Fm"}); koko体育-koko体育app koko体育-koko体育网页版koko体育app koko体育-全站app下载(官网) m6米乐app|下载 m6米乐app|主頁欢迎您!!