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宋昊岚, 杨婷婷, 李贵星. N末端脑利钠肽前体(NT-proBNP)在评估慢性肾脏疾病患者心功能中的价值[J]. koko体育app 学报(医学版), 2017, 48(4): 561-565.
引用本文: 宋昊岚, 杨婷婷, 李贵星. N最末端脑利钠肽前体(NT-proBNP)在监测慢性的肾脏疾病人者心功能模块中的使用价值[J]. 湖南社会学报(中医药学版), 2017, 48(4): 561-565.
SONG Haolan, YANG Tingting, LI Guixing. Assessing Cardiac Function of Patients with Chronic Kidney Disease using N-Terminal Pro-brain Natriuretic [J]. Journal of Sichuan University (Medical Sciences), 2017, 48(4): 561-565.
Citation: SONG Haolan, YANG Tingting, LI Guixing. Assessing Cardiac Function of Patients with Chronic Kidney Disease using N-Terminal Pro-brain Natriuretic [J]. Journal of Sichuan University (Medical Sciences), 2017, 48(4): 561-565.

N末端脑利钠肽前体(NT-proBNP)在评估慢性肾脏疾病患者心功能中的价值

Assessing Cardiac Function of Patients with Chronic Kidney Disease using N-Terminal Pro-brain Natriuretic 

  • 摘要: 目的探讨慢性肾脏疾病(CKD)患者N末端脑利钠肽前体(NT-proBNP)水平及在评价CKD患者心功能中的价值。方法收集2013年1月至2014年12月以慢性肾脏相关疾病为主诊的住院患者567例,按其估算肾小球滤过率分为6组,结合患者心功能分级,分析其血浆NT-proBNP水平与肾功能、心功能的相关性以及CKD患者诊断心功能衰竭的截断值。结果CKD患者心功能越差,血浆NT-proBNP质量浓度越高;估算肾小球滤过率越低,血浆NT-proBNP质量浓度越高,且两者间呈负相关(r=-0.529,P<0.01);通过绘制受试者工作特征曲线(ROC曲线),在CKD不同分期的患者中诊断心功能衰竭的NT-proBNP界值分别为G1:119.5 ng/L,G2: 168.5 ng/L,G3a: 300.5 ng/L,G3b: 1 019.5 ng/L,G4: 2 777.5 ng/L,G5: 3 640.5 ng/L。结论血浆NT-proBNP水平受肾脏功能影响,与估算肾小球滤过率存在负相关,建议对CKD患者应用NT-proBNP进行心脏功能评估时,应考虑采用不同的界断值。  
    Abstract: Objective To determine the plasma level of N-terminal brain natriuretic peptide precursor (NT-proBNP) in patients with chronic kidney disease (CKD) and its association with cardiac function. Methods A total of 567 CKD patients admitted to the hospital from January 2013 to December 2014 were divided into six groups according to their estimated glomerular filtration rate. Their plasma level of NT-proBNP, renal function, and cardiac function were determined. Results The worse patients cardiac function,and the lower eGFR,the higher concentration of plasma NT-proBNP. Plasma level of NT-proBNP was negatively correlated with glomerular filtration rate (=-0.529, P<0.01). The receiver operating characteristic curves generated a cutoff NT-proBNP value of 119.5 ng/L, 168.5 ng/L, 300.5 ng/L, 1 019.5 ng/L, 2 777.5 ng/L, and 3 640.5 ng/L, respectively, for diagnosing cardiac failure in the six groups, respectively. Conclusion NT-proBNP is affected by renal function, which can be used for diagnosing cardiac failure in patients with CKD.   
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