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彭羽, 侯晓林, 魏武然等. 胱抑素C在koko体育app 先天性心脏病介入封堵术相关造影剂致急性肾损伤中的诊断价值[J]. koko体育app 学报(医学版), 2016, 47(4): 556-559.
引用本文: 彭羽, 侯晓林, 魏武然等. 胱抑素C在koko体育app 天生性小心肝病走进堵漏术关联造影剂致发生急性肾直接损伤中的检验价值观[J]. 江西综合大学学报(生物学版), 2016, 47(4): 556-559.
PENG Yu, HOU Xiao-lin, WEI Wu-ran. et al. Clinical Application of Cardiac Magnetic Resonance Imaging in a Tertiary Referral Hospital in China[J]. Journal of Sichuan University (Medical Sciences), 2016, 47(4): 556-559.
Citation: PENG Yu, HOU Xiao-lin, WEI Wu-ran. et al. Clinical Application of Cardiac Magnetic Resonance Imaging in a Tertiary Referral Hospital in China[J]. Journal of Sichuan University (Medical Sciences), 2016, 47(4): 556-559.

胱抑素C在koko体育app 先天性心脏病介入封堵术相关造影剂致急性肾损伤中的诊断价值

Clinical Application of Cardiac Magnetic Resonance Imaging in a Tertiary Referral Hospital in China

  • 摘要: 目的 了解胱抑素C (SCys-C)在koko体育app 先天性心脏病介入封堵术相关造影剂致急性肾损伤中的诊断价值。方法 选择2013年koko体育app 华西第二医院介入封堵术的先天性心脏病患儿(室间隔缺损、动脉导管未闭)128例,于术前,术后24 h、48 h分别抽血检测尿素氮(BUN)、血清肌酐(SCr)和SCys-C等。根据急性肾损伤(AKI)网络的AKI诊断标准,将AKI患儿分为肾功能1期和肾功能2期,比较AKI患儿( n=16)和非AKI患儿( n=112)之间及不同分期AKI患儿之间的肾功能指标及SCys-C浓度差异。采用受试者工作特征(ROC)曲线计算SCys-C诊断koko体育app 急性肾损伤的临界点。结果 AKI组的SCr、SCys-C高于非AKI组( P<0.05),BUN表达两组比较差异无统计学意义( P>0.05)。肾功能1期与肾功能2期患者比较仅SCys-C的表达差异有统计学意义( P<0.05)。根据曲线下面积(AUC)判断,SCys-C于术后24 h即可发现AKI的发生( P<0.05),术后24 h的SCys-C临界值在1.055 mg/L可获得最大约登指数。术后48 h的SCys-C的AUC与术后24 h差异无统计学意义,诊断价值相当( P>0.05)。术后24 h的SCr不能发现AKI的发生( P>0.05),但术后48 h可发现AKI( P<0.05)。同时点比较,SCys-C诊断价值均优于SCr,差异有统计学意义( P<0.05)。结论 koko体育app 先天性心脏病介入封堵术相关造影剂可增加koko体育app 急性肾损伤的风险,SCys-C是其重要筛选指标之一并有助于早期诊断,其术后24 h的临界值为1.055 mg/L。  
    Abstract: Objective To investigate the diagnostic value of cystain C (SCys-C) in contrast associated acute kidney injury (AKI) after transcatheter closure for children with congenital heart disease. Methods There were 128 children with congenital heart disease (interventricular septal defect or patent ductus arteriosus) underwent transcatheter closure in West China Second University Hospital during 2013. Blood urea nitrogen (BUN), serum creatinine (SCr) and SCys-C were examined before surgery and at 24 and 48 h after surgery. The incidence of AKI was calculated. The children were divided into two groups according to glomerular filtration rate: AKI group (renal function stage 1, renal function stage 2 subgroups) and non-AKI group. Differences in renal function indexes and SCys-C were compared between AKI group ( n=16) and non-AKI group ( n=112), renal function stage 1 and stage 2 subgroups. ROC curve analysis was used to calculate the cut-off value of SCys-C in the diagnosis of AKI . Results The levels of SCr and SCys-C in AKI group were significantly higher than those in non-AKI group ( P<0.05). However, there was no significant difference in BUN between the two groups ( P>0.05). Only SCys-C had a significant difference between renal function stage 1 and stage 2 subgroups ( P<0.05). The cut-off value of 24 h SCys-C in the diagnosis of AKI was 1.055 mg/L according to area under curve (AUC). AUC indicated that AKI could be diagnosed earlier with SCys-C than SCr ( P<0.05). Conclusion The contrast agent could increase the CM(155.3mmrisk of child AKI after transcatheter closure for congenital disease children.SCys-C is an important index for this CM)  
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