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潘国莹, 张吉傲笛, 梁永平, 等. 刺激响应性水凝胶伤口敷料用于糖尿病慢性伤口修复的研究进展[J]. koko体育app 学报(医学版), 2023, 54(4): 726-730. DOI:
引用本文: 潘国莹, 张吉傲笛, 梁永平, 等. 刺激响应性水凝胶伤口敷料用于糖尿病慢性伤口修复的研究进展[J]. koko体育app 学报(医学版), 2023, 54(4): 726-730. DOI:
PAN Guoying, ZHANG Ji'aodi, LIANG Yongping, et al. Latest Findings on Stimuli-Responsive Hydrogel Wound Dressings Applied in Diabetic Chronic Wound Repair[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(4): 726-730. DOI:
Citation: 🍸 PAN Guoying, ZHANG Ji'aodi, LIANG Yongping, et al. Latest Findings on Stimuli-Responsive Hydrogel Wound Dressings Applied in Diabetic Chronic Wound Repair[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(4): 726-730. DOI:

刺激响应性水凝胶伤口敷料用于糖尿病慢性伤口修复的研究进展

Latest Findings on Stimuli-Responsive Hydrogel Wound Dressings Applied in Diabetic Chronic Wound Repair

  • 摘要: 糖尿病慢性伤口给糖尿病患者带来了巨大的心理负担和经济负担。传统的伤口敷料功能单一,伤口环境适配性不足,难以满足愈合过程的复杂需求。刺激响应性水凝胶可以对伤口区域的特殊环境(例如温度、pH、葡萄糖等)产生特异性反应,并通过负载活性物质实现按需响应释放,能够有效促进糖尿病伤口愈合。本文结合近年来刺激响应伤口敷料的研究进展及本课题组的相关研究,对具有温度、pH、葡萄糖、活性氧、酶以及多重刺激响应的水凝胶伤口敷料进行了总结和讨论。根据糖尿病伤口特殊的生理环境,可以设计具有单一或多重刺激响应性的水凝胶,按需释放药物,改善伤口的微环境,从而满足伤口愈合不同阶段的需求。尽管目前刺激响应性水凝胶展现出了极佳的治疗潜力,但是仍然有进一步发展的空间:伤口敷料中负载的细胞或细胞因子通常只在特定的愈合阶段起作用,需要对时间进行精准控制以避免对伤口愈合造成反作用。另外,构建传感治疗一体化器件实时监测伤口生化指标,按需精准释放药物以促进伤口愈合也是值得研究的课题之一。  
    Abstract: Diabetic chronic wounds entail enormous psychological and economic burdens on diabetic patients. Traditional types of wound dressings lack diversity in their functions and do not have sufficient adaptability to the wound environment, which makes it difficult to meet the complicated needs arising during the healing process when they are used. Stimuli-responsive hydrogels respond specifically to the special environment of the wound area, for example, temperature, pH, glucose, etc., and achieve on-demand release by loading active substances, which effectively promotes diabetic wound healing. Herein, based on the research progress in stimulus-responsive wound dressings in recent years and the relevant work of our research team, we summarized and discussed hydrogel wound dressings responsive to temperature, pH, glucose, reactive oxygen species, enzymes, and multiple stimuli. Based on the special physiological environment of diabetic wounds, hydrogels with single or multiple stimuli-responsive properties can be designed so that they can release drugs on demand and improve the microenvironment of the wound, thus meeting the specific needs of different stages of wound healing. Although stimuli-responsive hydrogels currently show excellent therapeutic potential, there is still room for further development—cells or cytokines loaded in wound dressings usually act only at specific healing stages and the timing needs to be precisely controlled in order to avoid counterproductive effects on wound healing. In addition, the construction of sensor-therapeutic integrated devices for real-time monitoring of wound biochemical indicators so that drugs are release on demand and with precision to promote wound healing is also one of the topics that deserve more attention from researchers.  

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