koko体育app

欢迎来到《koko体育app 学报（医学版）》
影响初始化失败性水疑胶创伤敷料用到痛风急慢性创伤复原的钻研近展

潘国莹,  张吉傲笛,  梁永平,  郭保林

潘国莹, 张吉傲笛, 梁永平, 等. 刺激响应性水凝胶伤口敷料用于糖尿病慢性伤口修复的研究进展[J]. koko体育app 学报（医学版）, 2023, 54(4): 726-730. doi: 10.12182/20230760206
引用本文: 潘国莹, 张吉傲笛, 梁永平, 等. 刺激响应性水凝胶伤口敷料用于糖尿病慢性伤口修复的研究进展[J]. koko体育app 学报（医学版）, 2023, 54(4): 726-730. doi:
PAN Guoying, ZHANG Ji'aodi, LIANG Yongping, et al. Latest Findings on Stimuli-Responsive Hydrogel Wound Dressings Applied in Diabetic Chronic Wound Repair[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2023, 54(4): 726-730. doi: 10.12182/20230760206
Citation: PAN Guoying, ZHANG Ji'aodi, LIANG Yongping, et al. Latest Findings on Stimuli-Responsive Hydrogel Wound Dressings Applied in Diabetic Chronic Wound Repair[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2023, 54(4): 726-730. doi:

刺激响应性水凝胶伤口敷料用于糖尿病慢性伤口修复的研究进展

doi: 
  • 杭州交通银行大学时深入分析科学学技巧深入分析院 （杭州 710049）
基金项目: 国家自然科学基金（No. 51973172 、No. 52273149）和中国博士后科学基金（No. 2022M712498）资助
详细信息
    通讯作者:

    梁永平，E-mail：liangyp@xjtu.edu.cn

    郭保林，E-mail：baoling@mail.xjtu.edu.cn

Latest Findings on Stimuli-Responsive Hydrogel Wound Dressings Applied in Diabetic Chronic Wound Repair

  • Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China
More Information
  • 摘要: 糖尿病慢性伤口给糖尿病患者带来了巨大的心理负担和经济负担。传统的伤口敷料功能单一，伤口环境适配性不足，难以满足愈合过程的复杂需求。刺激响应性水凝胶可以对伤口区域的特殊环境（例如温度、pH、葡萄糖等）产生特异性反应，并通过负载活性物质实现按需响应释放，能够有效促进糖尿病伤口愈合。本文结合近年来刺激响应伤口敷料的研究进展及本课题组的相关研究，对具有温度、pH、葡萄糖、活性氧、酶以及多重刺激响应的水凝胶伤口敷料进行了总结和讨论。根据糖尿病伤口特殊的生理环境，可以设计具有单一或多重刺激响应性的水凝胶，按需释放药物，改善伤口的微环境，从而满足伤口愈合不同阶段的需求。尽管目前刺激响应性水凝胶展现出了极佳的治疗潜力，但是仍然有进一步发展的空间：伤口敷料中负载的细胞或细胞因子通常只在特定的愈合阶段起作用，需要对时间进行精准控制以避免对伤口愈合造成反作用。另外，构建传感治疗一体化器件实时监测伤口生化指标，按需精准释放药物以促进伤口愈合也是值得研究的课题之一。
    Abstract: Diabetic chronic wounds entail enormous psychological and economic burdens on diabetic patients. Traditional types of wound dressings lack diversity in their functions and do not have sufficient adaptability to the wound environment, which makes it difficult to meet the complicated needs arising during the healing process when they are used. Stimuli-responsive hydrogels respond specifically to the special environment of the wound area, for example, temperature, pH, glucose, etc., and achieve on-demand release by loading active substances, which effectively promotes diabetic wound healing. Herein, based on the research progress in stimulus-responsive wound dressings in recent years and the relevant work of our research team, we summarized and discussed hydrogel wound dressings responsive to temperature, pH, glucose, reactive oxygen species, enzymes, and multiple stimuli. Based on the special physiological environment of diabetic wounds, hydrogels with single or multiple stimuli-responsive properties can be designed so that they can release drugs on demand and improve the microenvironment of the wound, thus meeting the specific needs of different stages of wound healing. Although stimuli-responsive hydrogels currently show excellent therapeutic potential, there is still room for further development—cells or cytokines loaded in wound dressings usually act only at specific healing stages and the timing needs to be precisely controlled in order to avoid counterproductive effects on wound healing. In addition, the construction of sensor-therapeutic integrated devices for real-time monitoring of wound biochemical indicators so that drugs are release on demand and with precision to promote wound healing is also one of the topics that deserve more attention from researchers.
    • HTML全文
  • [1] LIANG Y, HE J, GUO B. Functional hydrogels as wound dressing to enhance wound healing. ACS Nano,2021,15(8): 12687–12722. doi:
    [2] ZHAO X, PEI D, YANG Y, et al. Green tea derivative driven smart hydrogels with desired functions for chronic diabetic wound treatment. Adv Funct Mater,2021,31(18): 2009442. doi:
    [3] El-SHEWY K M, KUNBAZ A, GAD M M, et al. Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: a narrative review. Biomed Pharmacother,2019,109: 629–638. doi:
    [4] DENG Z, YU R, GUO B. Stimuli-responsive conductive hydrogels: design, properties, and applications. Mater Chem Front,2021,5(5): 2092–2123. doi:
    [5] WANG S Y, KIM H, KWAK G, et al. Development of biocompatible ha hydrogels embedded with a new synthetic peptide promoting cellular migration for advanced wound care management. Adv Sci,2018,5(11): 1800852. doi:
    [6] LAVRADOR P, ESTEVES M R, GASPAR V M, et al. Stimuli-responsive nanocomposite hydrogels for biomedical applications. Adv Funct Mater,2021,31(8): 2005941. doi:
    [7] MARQUES A C, COSTA P J, VELHO S, et al. Stimuli-responsive hydrogels for intratumoral drug delivery. Drug Discovery Today,2021,26(10): 2397–2405. doi:
    [8] SAPINO S, CHIRIO D, PEIRA E, et al. Ocular drug delivery: a special focus on the thermosensitive approach. Nanomater,2019,9(6): 884. doi:
    [9] CHEN C, WANG Y, ZHANG H, et al. Responsive and self-healing structural color supramolecular hydrogel patch for diabetic wound treatment. Bioact Mater,2022,15: 194–202. doi:
    [10] JIANG Y, ZHANG X, ZHANG W, et al. Infant skin friendly adhesive hydrogel patch activated at body temperature for bioelectronics securing and diabetic wound healing. ACS Nano,2022,16(6): 8662–8676. doi:
    [11] MOREY M, PANDIT A. Responsive triggering systems for delivery in chronic wound healing. Adv Drug Delivery Rev,2018,129: 169–193. doi:
    [12] WANG T, ZHENG Y, SHI Y, et al. pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharide promotes diabetic wound healing by enhancing angiogenesis and antibacterial activity. Drug Deliv Transl Res,2019,9(1): 227–239. doi:
    [13] LIU X, DOU G, LI Z, et al. Hybrid biomaterial initiates refractory wound healing via inducing transiently heightened inflammatory responses. Adv Sci,2022,9(21): 2105650. doi:
    [14] ZENG Y, ZHU C, TAO L. Stimuli-responsive multifunctional phenylboronic acid polymers via multicomponent reactions: from synthesis to application. Macromol Rapid Commun,2021,42(18): 2100022. doi:
    [15] HU C, LONG L, CAO J, et al. Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release. Chem Engineer J,2021,411(6): 128564. doi:
    [16] LIANG Y, LI M, YANG Y, et al. pH/glucose dual responsive metformin release hydrogel dressings with adhesion and self-healing via dual-dynamic bonding for athletic diabetic foot wound healing. ACS Nano,2022,16(2): 3194–3207. doi:
    [17] JIA Y, ZHANG X, YANG W, et al. A pH-responsive hyaluronic acid hydrogel for regulating the inflammation and remodeling of the ECM in diabetic wounds. J Mater Chem B,2022,10(15): 2875–2888. doi:
    [18] LIU S, ZHENG R, CHEN S, et al. A compliant, self-adhesive and self-healing wearable hydrogel as epidermal strain sensor. J Mater Chem C,2018,6(15): 4183–4190. doi:
    [19] LEI H, FAN D. A combination therapy using electrical stimulation and adaptive, conductive hydrogels loaded with self-assembled nanogels incorporating short interfering rna promotes the repair of diabetic chronic wounds. Adv Sci,2022,9(30): 2201425. doi:
    [20] FU L H, QI C, LIN J, et al. Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment. Chem Soc Rev,2018,47(17): 6454–6472. doi:
    [21] YANG J, ZENG W, XU P, et al. Glucose-responsive multifunctional metal–organic drug-loaded hydrogel for diabetic wound healing. Acta Biomater,2022,140: 206–218. doi:
    [22] SHEN D, YU H, WANG L, et al. Recent progress in design and preparation of glucose-responsive insulin delivery systems. J Controlled Release,2020,321: 236–258. doi:
    [23] FUCHS S, ERNST A U, WANG L H, et al. Hydrogels in emerging technologies for type 1 diabetes. Chem Rev,2021,121(18): 11458–11526. doi:
    [24] YIN R, HE J, BAI M, et al. Engineering synthetic artificial pancreas using chitosan hydrogels integrated with glucose-responsive microspheres for insulin delivery. Mater Sci Eng C,2019,96: 374–382. doi:
    [25] FUJISAKI H, WATCHARAWITTAYAKUL T, MATSUMOTO A, et al. In-situ chemical modification of printed conducting polymer films for specific glucose biosensing. Sens Actuators B,2021,349: 130829. doi:
    [26] XU Z, LIU G, HUANG J, et al. Novel glucose-responsive antioxidant hybrid hydrogel for enhanced diabetic wound repair. ACS Appl Mater Interfaces,2022,14(6): 7680–7689. doi:
    [27] WANG P, GONG Q, HU J, et al. Reactive oxygen species (ROS)-responsive prodrugs, probes, and theranostic prodrugs: applications in the ROS-related diseases. J Mater Chem,2021,64(1): 298–325. doi:
    [28] ZHAO H, HUANG J, LI Y, et al. ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds. Biomaterials,2020,258: 120286. doi:
    [29] CHENG P, CHENG L, HAN H, et al. A pH/H2O2/MMP9 time-response gel system with sparchigh tregs derived extracellular vesicles promote recovery after acute myocardial infarction. Adv Funct Mater,2022,11(22): 2200971. doi:
    [30] ZHOU W, DUAN Z, ZHAO J, et al. Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing. Bioact Mater,2022,17: 1–17. doi:
    [31] OLIVA N, ALMQUIST B D. Spatiotemporal delivery of bioactive molecules for wound healing using stimuli-responsive biomaterials. Adv Drug Delivery Rev,2020,161-162: 22–41. doi:
    [32] GUO H, BAI M, ZHU Y, et al. Pro-healing zwitterionic skin sensor enables multi-indicator distinction and continuous real-time monitoring. Adv Funct Mater,2021,31(50): 2106406. doi:
  • 加载中
© 2023《河南二本大学学报（药学版）》复制部 版权登记每个

🍌对外开放了解 本文遵循知识共享署名—非商业性使用4.0国际许可协议（CC BY-NC 4.0），允许第三方对本刊发表的论文自由共享（即在任何媒介以任何形式复制、发行原文）、演绎（即修改、转换或以原文为基础进行创作），必须给出适当的署名，提供指向本文许可协议的链接，同时标明是否对原文作了修改；不得将本文用于商业目的。CC BY-NC 4.0许可协议详情请访问 //creativecommons.org/licenses/by-nc/4.0

计量
  • 文章访问数:  7
  • HTML全文浏览量:  0
  • PDF下载量:  0
  • 被引次数: 0
出版历程
  • 收稿日期:  2024-05-06
  • 修回日期:  2024-06-26
  • 网络出版日期:  2024-07-31
  • 刊出日期:  2024-07-20

目录

    /

    返回文章
    返回
    var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.src = "https://hm.baidu.com/hm.js?90c4d9819bca8c9bf01e7898dd269864"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); koko体育-koko体育app koko体育-koko体育网页版koko体育app koko体育-全站app下载(官网) m6米乐app|下载 m6米乐app|主頁欢迎您!!