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水凝露载药体系在牙体炎治疗方法中的研究方案进况

曾欣,  刘帆

曾欣, 刘帆. 水凝胶载药系统在牙周炎治疗中的研究进展[J]. koko体育app 学报（医学版）, 2023, 54(4): 721-725. doi: 10.12182/20230760203
引用本文: 曾欣, 刘帆. 水凝胶载药系统在牙周炎治疗中的研究进展[J]. koko体育app 学报（医学版）, 2023, 54(4): 721-725. doi:
ZENG Xin, LIU Fan. Latest Findings on Hydrogel Drug Delivery Systems in the Treatment of Periodontitis[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2023, 54(4): 721-725. doi: 10.12182/20230760203
Citation: ZENG Xin, LIU Fan. Latest Findings on Hydrogel Drug Delivery Systems in the Treatment of Periodontitis[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2023, 54(4): 721-725. doi:

水凝胶载药系统在牙周炎治疗中的研究进展

doi: 
  • 1. 江苏大学专业华西护里职业技术学院 （程度 610041）
  • 2. 牙齿部位问题研究探讨方案一个发展中国家着重科学试验室 一个发展中国家牙齿部位问题临床检验中医学研究探讨方案主 重庆读书华西牙齿部位医疗机构 （武汉 610041）
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    通讯作者:

    E-mail：liufan@dikai.net.cn

Latest Findings on Hydrogel Drug Delivery Systems in the Treatment of Periodontitis

  • 1. West China School of Nursing, Sichuan University, Chengdu 610041, China
  • 2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
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  • 摘要: 水凝胶载药系统具备独特的结构和性能，可注入并滞留在牙周，局部缓释和控释具有抗菌、抗炎及促进牙周组织再生功效的药物，具备安全性、实用性和有效性，在牙周炎治疗中极具潜力。本文综述了水凝胶载药系统在牙周炎治疗中的概况，包括搭载药物的分类及形式、常见的水凝胶基质及其优缺点；指出水凝胶载药系统在牙周炎治疗中所需的性能，包括一定的黏度、合适的降解周期和温敏性；总结了水凝胶载药系统在牙周炎治疗中的刺激响应类型，包括pH响应型、酶响应型、活性氧响应型、光响应型和糖响应型。未来的研究可进一步探究水凝胶载药系统的临床疗效并促进其转化应用，探究搭载生物药物的水凝胶载药系统以促进牙周组织再生领域的进展，明确和探索智能水凝胶载药系统的响应来源、实现策略和安全的制备方式以实现更为高效、安全地给药。除搭载药物外，探究具有药用价值的水凝胶基质也值得期待。
    Abstract: Hydrogel drug delivery systems possess unique structures and properties and hence can be injected and retained in the periodontal pocket for slow and controlled release of medications with antibacterial, anti-inflammatory, and periodontal tissue regeneration-promotional effects. Due to their safety, practicability, and effectiveness, they show great potential in the treatment of periodontitis. In this paper, we gave an overview of hydrogel drug delivery systems in the treatment of periodontitis, summing up the classification and forms of the drugs delivered and the strengths and weaknesses of common types of hydrogel matrixes. In addition, we discussed properties required for hydrogel drug delivery systems applicable in the treatment of periodontitis, including a certain level of viscosity, suitable degradation cycle, and temperature sensitivity. Finally, we summarized the stimulus responsiveness types of hydrogel drug delivery systems applicable in the treatment of periodontitis, including pH-responsiveness, enzyme-responsiveness, reactive oxygen species-responsiveness, light-responsiveness, and sugar-responsiveness. In the future, researchers should make further investigation into the clinical efficacy of hydrogel drug delivery systems and promote their translation into clinical applications. Additionally, hydrogel drug delivery systems carrying biologic drugs could be further investigated to promote advancement in the field of periodontal tissue regeneration. Furthermore, the response sources, realization strategies, and safe preparation methods of smart hydrogel drug delivery systems should also be further clarified and explored to achieve drug delivery of better efficiency and safety. In addition to drug delivery, hydrogel matrixes with medicinal values also show great promises.
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出版历程
  • 收稿日期:  2024-04-28
  • 修回日期:  2024-06-25
  • 网络出版日期:  2024-07-31
  • 刊出日期:  2024-07-20

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