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屠叶, 徐欣, 周学东. 生命早期口腔菌群的定植及影响因素[J]. koko体育app 学报(医学版), 2022, 53(2): 220-225. DOI:
引用本文: 屠叶, 徐欣, 周学东. 生命早期口腔菌群的定植及影响因素[J]. koko体育app 学报(医学版), 2022, 53(2): 220-225. DOI:
TU Ye, XU Xin, ZHOU Xue-dong. Development and Influencing Factors of Oral Microbiota in Early Life[J]. Journal of Sichuan University (Medical Sciences), 2022, 53(2): 220-225. DOI:
Citation: TU Ye, XU Xin, ZHOU Xue-dong. Development and Influencing Factoไrs of Oral Microbiota in Early Life[J]. Journal of Sichuan University (Medical Sciences), 2022, 53(2): 220-225. DOI:

生命早期口腔菌群的定植及影响因素

Development and Influencing Factors of Oral Microbiota in Early Life

  • 摘要: 口腔作为人体消化系统的重要组成部分和门户,是微生物重要的定植位点和微生态环境。正常口腔微生态的建立和演替对人体免疫系统的发育,以及口腔和全身健康具有重要意义。新生儿出生几小时后口腔就已经出现了链球菌属、乳杆菌属等先锋菌群的定植;随着宿主年龄的增长,口腔菌群的物种丰富度和多样性随之增加,菌群结构趋于成熟。多项横断面研究发现生命早期口腔微生态系统的发展不仅与遗传因素有关,还受到包括母亲健康状况、出生方式、喂养方式、抗生素使用等多种外界因素的影响。生命早期口腔微生态失衡与口腔以及全身疾病的发生发展密切相关,良好的口腔卫生习惯,对口腔细菌性疾病的早期管理和有效防控具有重要的意义。本文总结了生命早期阶段口腔菌群定植及演替的规律,并对影响生命早期口腔微生态系统的外界因素以及生命早期口腔菌群对后期宿主健康的影响进行了讨论,以期对全生命周期口腔及全身健康管理提供新思路和新策略。  
    Abstract: Oral cavity, an important component of and the gateway to the digestive system, is also the colonization site and the microecological environment of trillions of microorganisms. The establishment and succession of oral microbiota are of great importance for the development of human immune system, and function as a major determinant of oral and systemic health. Within a few hours after birth, early colonizers such as Streptococcus and Lactobacillus can be detected in an infant’s mouth. The oral microbiota communities mature gradually along with the growth of the host, expanding in their species abundance and diversity. In addition to genetic factors, a number of cross-sectional studies have revealed that the development of oral microecosystems in early life is influenced and tuned by multiple external factors, including maternal health status, mode of delivery, feeding habits, antibiotics use, etc. The dysbiosis of oral microecology in early life is closely related to the pathogenesis and progression of oral and systemic diseases. Therefore, good oral hygiene habits are of vital importance to the early management of oral microbial diseases and their effective prevention and control. Herein, we summarized the colonization and succession of oral microbiota in early life and further discussed the key external factors that affect early life oral microecosystem, as well as the impact of early life oral microbiota on the host's health at a later stage, intending to help providing new insights into and new strategies for the management of the whole lifecycle oral and systemic health.  
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