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口腔微生物及宿主细胞氨基酸代谢与口腔疾病相关性研究进展
Research Progress in the Association between Amino Acid Metabolism of Oral Microorganisms and Host Cells and Oral Diseases
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摘要: 氨基酸作为蛋白质的合成底物，是细胞内仅次于葡萄糖的重要能量和营养来源。微生物和宿主细胞均能进行氨基酸代谢，其代谢产物广泛参与炎症、免疫反应等生物学过程。探究疾病发生发展过程中微生物与宿主氨基酸代谢变化成为新的研究热点。本文将对色氨酸、精氨酸等氨基酸代谢途径及其产物与龋病、牙周病、舍格伦综合征，甚至口腔肿瘤等常见口腔疾病发生发展相关研究进展做一综述，以期为深入理解口腔疾病致病机制和指导临床治疗提供理论依据。Abstract: Amino acids, the substrate of protein synthesis, are an important source of energy and nutrition, second only to glucose. Previous studies have found that both microorganisms and their host cells can metabolize amino acids, and the metabolites are widely involved in the regulation of various biological processes, including inflammation and immune response. Exploring the changes in amino acid metabolism during the pathogenesis and progression of diseases has become a new hot topic of research. We summarized in this review the research progress in the pathogenesis and progression of common oral diseases, including dental caries, periodontal diseases, Sjögren’s syndrome, and even oral tumors, related to metabolism pathways of amino acids, especially tryptophan and arginine, and their metabolites, attempting to provide a theoretical basis for enhancing understanding of the pathogenic mechanism of the oral diseases, as well as guidance for clinical treatment.
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