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仇学梅, 李鑫, 刘锐. 非编码RNA与先天免疫信号调控[J]. koko体育app 学报（医学版）, 2022, 53(1): 20-27. DOI:
引用本文: 仇学梅, 李鑫, 刘锐. 非编码RNA与先天免疫信号调控[J]. koko体育app 学报（医学版）, 2022, 53(1): 20-27. DOI:
QIU Xue-mei, LI Xin, LIU Rui. Non-Coding RNA and Innate Immune Signal Regulation[J]. Journal of Sichuan University (Medical Sciences), 2022, 53(1): 20-27. DOI:
Citation: QIU Xue-mei, LI Xin, LIU Rui. Non-Coding RNA and Innate Immune Signal Regulation[J]. Journal of Sichuan University (ꦯMedical Sciences), 2022, 53(1): 20-27. DOI:

非编码RNA与先天免疫信号调控

Non-Coding RNA and Innate Immune Signal Regulation

  • 摘要: 先天免疫对消除和控制感染至关重要，但不受控制的免疫反应可损伤宿主组织。机体免疫稳态的调节是一个精确的、复杂的过程，其中，非编码RNA是多种生物过程中的重要调控因子。目前研究表明微小RNA、长链非编码RNA通过调控先天免疫途径中的基因表达参与抗病毒反应、肿瘤免疫及自身免疫性疾病。通常情况下，微小RNA通过与mRNA的3′端非翻译区结合，在转录后水平调节基因表达，而长链非编码RNA则作为微小RNA的内源竞争RNA，抑制微小RNA与信使RNA的结合，发挥免疫调控作用。本综述总结了非编码RNA在先天免疫中的调节作用及其机制，为先天免疫的调节及免疫相关疾病的研究提供参考。同时，koko体育app 也展望了该领域未来的研究方向，包括新型非编码RNA的表达与成熟调控机制，以及非编码RNA在进化中的保守性等。  
    Abstract: The innate immune system is critical to the elimination and control of infections. However, uncontrolled immune responses can cause indirect host-mediated tissue damage. The regulation of immune homeostasis is a complex but finely regulated process. ncRNAs have been increasingly identified as important regulators of a variety of biological processes. Recent research findings suggest that microRNAs and long non-coding RNAs participate in antiviral responses, tumor immunity, and autoimmune diseases by regulating gene expression in the innate immune pathways. MicroRNAs regulate gene expression at the post-transcriptional level by binding to the 3′ untranslated regions of mRNA, while long non-coding RNAs act as endogenous competing RNAs for microRNAs, inhibiting the binding of microRNAs and mRNAs. In this review, we summarized the regulatory role of non-coding RNAs in innate immunity and its mechanism to provide references for research in the regulation of innate immunity and immune-related diseases. In addition, we also reported discussions on the future research directions in the field, including the expression and maturation regulation mechanism of new non-coding RNAs, and the conservation of non-coding RNAs in evolution.  
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